FastJM - Semi-Parametric Joint Modeling of Longitudinal and Survival Data

Maximum likelihood estimation for the semi-parametric joint modeling of competing risks and longitudinal data applying customized linear scan algorithms, proposed by Li and colleagues (2022) <doi:10.1155/2022/1362913>. The time-to-event data is modelled using a (cause-specific) Cox proportional hazards regression model with time-fixed covariates. The longitudinal outcome is modelled using a linear mixed effects model. The association is captured by shared random effects. The model is estimated using an Expectation Maximization algorithm.

Last updated 9 months ago

cppcpp

4.35 score 5 stars 1 packages 2 scripts 318 downloads

PDXpower - Time to Event Outcome in Experimental Designs of Pre-Clinical Studies

Conduct simulation-based customized power calculation for clustered time to event data in a mixed crossed/nested design, where a number of cell lines and a number of mice within each cell line are considered to achieve a desired statistical power, motivated by Eckel-Passow and colleagues (2021) <doi:10.1093/neuonc/noab137> and Li and colleagues (2024) <doi:10.48550/arXiv.2404.08927>. This package provides two commonly used models for powering a design, linear mixed effects and Cox frailty model. Both models account for within-subject (cell line) correlation while holding different distributional assumptions about the outcome. Alternatively, the counterparts of fixed effects model are also available, which produces similar estimates of statistical power.

Last updated 4 months ago

3.65 score 1 stars 2 scripts 155 downloads

JMH - Joint Model of Heterogeneous Repeated Measures and Survival Data

Maximum likelihood estimation for the semi-parametric joint modeling of competing risks and longitudinal data in the presence of heterogeneous within-subject variability, proposed by Li and colleagues (2023) <arXiv:2301.06584>. The proposed method models the within-subject variability of the biomarker and associates it with the risk of the competing risks event. The time-to-event data is modeled using a (cause-specific) Cox proportional hazards regression model with time-fixed covariates. The longitudinal outcome is modeled using a mixed-effects location and scale model. The association is captured by shared random effects. The model is estimated using an Expectation Maximization algorithm.

Last updated 9 months ago

3.48 score 3 stars 3 scripts 195 downloads